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Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes.

ABSTRACT: We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha heavy-chain genes in immunoglobulin M-expressing cells of the I.29 mu B-cell lymphoma, a cell line capable of switching to immunoglobulin A expression upon lipopolysaccharide treatment. This germ line alpha RNA has a small open reading frame that does not include the C alpha domain, and this RNA appears to be present on polysomes in I.29 mu cells.

SUBMITTER: Radcliffe G

PROVIDER: S-EPMC360760 | biostudies-other | 1990 Jan

REPOSITORIES: biostudies-other

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Structure of germ line immunoglobulin alpha heavy-chain RNA and its location on polysomes.

Radcliffe G G Lin Y C YC Julius M M Marcu K B KB Stavnezer J J

Molecular and cellular biology 19900101 1

We describe the structure of the major germ line RNA transcribed from unrearranged immunoglobulin alpha heavy-chain genes in immunoglobulin M-expressing cells of the I.29 mu B-cell lymphoma, a cell line capable of switching to immunoglobulin A expression upon lipopolysaccharide treatment. This germ line alpha RNA has a small open reading frame that does not include the C alpha domain, and this RNA appears to be present on polysomes in I.29 mu cells. ...[more]

PMID: 2152964

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Project description:This SuperSeries is composed of the SubSeries listed below.

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