Ontology highlight
ABSTRACT:
SUBMITTER: Hariharan IK
PROVIDER: S-EPMC398083 | biostudies-other | 1995 Jan
REPOSITORIES: biostudies-other
Hariharan I K IK Hu K Q KQ Asha H H Quintanilla A A Ezzell R M RM Settleman J J
The EMBO journal 19950101 2
The rho family of GTPases has been implicated in regulating changes in cell morphology in response to extracellular signals. We have cloned three widely expressed members of this family from Drosophila melanogaster; a rho homologue (Rho1) and two rac homologues (Rac1 and Rac2). Flies harbouring a Rho1 transgene that is specifically expressed in the eye exhibit a dramatic dose dependent disruption of normal eye development. Flies bearing at least two copies of the transgene display a severe rough ...[more]