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Comparison of MR-based attenuation correction and CT-based attenuation correction of whole-body PET/MR imaging.


ABSTRACT: The objective of this study was to evaluate the performance of the built-in MR-based attenuation correction (MRAC) included in the combined whole-body Ingenuity TF PET/MR scanner and compare it to the performance of CT-based attenuation correction (CTAC) as the gold standard.Included in the study were 26 patients who underwent clinical whole-body FDG PET/CT imaging and subsequently PET/MR imaging (mean delay 100 min). Patients were separated into two groups: the alpha group (14 patients) without MR coils during PET/MR imaging and the beta group (12 patients) with MR coils present (neurovascular, spine, cardiac and torso coils). All images were coregistered to the same space (PET/MR). The two PET images from PET/MR reconstructed using MRAC and CTAC were compared by voxel-based and region-based methods (with ten regions of interest, ROIs). Lesions were also compared by an experienced clinician.Body mass index and lung density showed significant differences between the alpha and beta groups. Right and left lung densities were also significantly different within each group. The percentage differences in uptake values using MRAC in relation to those using CTAC were greater in the beta group than in the alpha group (alpha group -0.2 ± 33.6%, R(2)?=?0.98, p?

SUBMITTER: Izquierdo-Garcia D 

PROVIDER: S-EPMC4090355 | biostudies-other | 2014 Aug

REPOSITORIES: biostudies-other

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Comparison of MR-based attenuation correction and CT-based attenuation correction of whole-body PET/MR imaging.

Izquierdo-Garcia David D   Sawiak Stephen J SJ   Knesaurek Karin K   Narula Jagat J   Fuster Valentin V   Machac Joseph J   Fayad Zahi A ZA  

European journal of nuclear medicine and molecular imaging 20140321 8


<h4>Purpose</h4>The objective of this study was to evaluate the performance of the built-in MR-based attenuation correction (MRAC) included in the combined whole-body Ingenuity TF PET/MR scanner and compare it to the performance of CT-based attenuation correction (CTAC) as the gold standard.<h4>Methods</h4>Included in the study were 26 patients who underwent clinical whole-body FDG PET/CT imaging and subsequently PET/MR imaging (mean delay 100 min). Patients were separated into two groups: the a  ...[more]

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