Ontology highlight
ABSTRACT:
SUBMITTER: Grosse J
PROVIDER: S-EPMC4121845 | biostudies-other | 2014 Jul
REPOSITORIES: biostudies-other
Grosse Johannes J Heffron Helen H Burling Keith K Akhter Hossain Mohammed M Habib Abdella M AM Rogers Gareth J GJ Richards Paul P Larder Rachel R Rimmington Debra D Adriaenssens Alice A AA Parton Laura L Powell Justin J Binda Matteo M Colledge William H WH Doran Joanne J Toyoda Yukio Y Wade John D JD Aparicio Samuel S Carlton Mark B L MB Coll Anthony P AP Reimann Frank F O'Rahilly Stephen S Gribble Fiona M FM
Proceedings of the National Academy of Sciences of the United States of America 20140715 30
The gut endocrine system is emerging as a central player in the control of appetite and glucose homeostasis, and as a rich source of peptides with therapeutic potential in the field of diabetes and obesity. In this study we have explored the physiology of insulin-like peptide 5 (Insl5), which we identified as a product of colonic enteroendocrine L-cells, better known for their secretion of glucagon-like peptide-1 and peptideYY. i.p. Insl5 increased food intake in wild-type mice but not mice lack ...[more]