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In vitro activities of nine antifungal drugs and their combinations against Phialophora verrucosa.

ABSTRACT: The in vitro activities of nine antifungal drugs and their combinations against 31 clinical and 15 environmental Phialophora verrucosa strains were tested. The MIC90/90% minimum effective concentration (MIC/MEC90) values (?g/ml) across all strains were as follows: for terbinafine, 0.25; for posaconazole, 0.5; for voriconazole, 1; for itraconazole, 2; for amphotericin B, 4; for caspofungin and micafungin, 16; and for fluconazole and flucytosine, 64. The highest synergy was shown by the combination of itraconazole plus caspofungin (with synergy against 100% of the 31 clinical strains), followed by amphotericin B plus flucytosine (45.2%) and itraconazole plus terbinafine or micafungin (25.8% or 12.9%, respectively).

SUBMITTER: Li Y

PROVIDER: S-EPMC4135824 | biostudies-other | 2014 Sep

REPOSITORIES: biostudies-other

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In vitro activities of nine antifungal drugs and their combinations against Phialophora verrucosa.

Li Yali Y Wan Zhe Z Li Ruoyu R

Antimicrobial agents and chemotherapy 20140630 9

The in vitro activities of nine antifungal drugs and their combinations against 31 clinical and 15 environmental Phialophora verrucosa strains were tested. The MIC90/90% minimum effective concentration (MIC/MEC90) values (μg/ml) across all strains were as follows: for terbinafine, 0.25; for posaconazole, 0.5; for voriconazole, 1; for itraconazole, 2; for amphotericin B, 4; for caspofungin and micafungin, 16; and for fluconazole and flucytosine, 64. The highest synergy was shown by the combinatio ...[more]

PMID: 24982078

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