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Continuous-Flow Synthesis and Derivatization of Aziridines through Palladium-Catalyzed C(sp(3) )-H Activation.

ABSTRACT: A continuous-flow synthesis of aziridines by palladium-catalyzed C(sp(3) )-H activation is described. The new flow reaction could be combined with an aziridine-ring-opening reaction to give highly functionalized aliphatic amines through a consecutive process. A predictive mechanistic model was developed and used to design the C-H activation flow process and illustrates an approach towards first-principles design based on novel catalytic reactions.

SUBMITTER: Zakrzewski J

PROVIDER: S-EPMC5094502 | biostudies-other | 2016 Jul

REPOSITORIES: biostudies-other

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Continuous-Flow Synthesis and Derivatization of Aziridines through Palladium-Catalyzed C(sp(3) )-H Activation.

Zakrzewski Jacek J Smalley Adam P AP Kabeshov Mikhail A MA Gaunt Matthew J MJ Lapkin Alexei A AA

Angewandte Chemie (International ed. in English) 20160615 31

A continuous-flow synthesis of aziridines by palladium-catalyzed C(sp(3) )-H activation is described. The new flow reaction could be combined with an aziridine-ring-opening reaction to give highly functionalized aliphatic amines through a consecutive process. A predictive mechanistic model was developed and used to design the C-H activation flow process and illustrates an approach towards first-principles design based on novel catalytic reactions. ...[more]

PMID: 27304395

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