Ontology highlight
ABSTRACT:
SUBMITTER: Alleva B
PROVIDER: S-EPMC5294783 | biostudies-other | 2017 Feb
REPOSITORIES: biostudies-other
Alleva Benjamin B Balukoff Nathan N Peiper Amy A Smolikove Sarit S
The Journal of cell biology 20170111 2
In meiotic prophase I, homologous chromosome pairing is promoted through chromosome movement mediated by nuclear envelope proteins, microtubules, and dynein. After proper homologue pairing has been established, the synaptonemal complex (SC) assembles along the paired homologues, stabilizing their interaction and allowing for crossing over to occur. Previous studies have shown that perturbing chromosome movement leads to pairing defects and SC polycomplex formation. We show that FKB-6 plays a rol ...[more]