Ontology highlight
ABSTRACT:
SUBMITTER: Bottecchia C
PROVIDER: S-EPMC5656832 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Angewandte Chemie (International ed. in English) 20170901 41
A mild visible-light-mediated strategy for cysteine arylation is presented. The method relies on the use of eosin Y as a metal-free photocatalyst and aryldiazonium salts as arylating agents. The reaction can be significantly accelerated in a microflow reactor, whilst allowing the in situ formation of the required diazonium salts. The batch and flow protocol described herein can be applied to obtain a broad series of arylated cysteine derivatives and arylated cysteine-containing dipeptides. Moreo ...[more]