Genetically Modified T-cell Infusion Following Peripheral Blood Stem Cell Transplant in Treating Patients With Recurrent or High-Risk Non-Hodgkin Lymphoma

ABSTRACT: This phase I trial studies the side effects and best dose of genetically modified T-cells following peripheral blood stem cell transplant in treating patients with recurrent or high-risk non-Hodgkin lymphoma. Giving chemotherapy before a stem cell transplant helps stop the growth of cancer cells. When the healthy stem cells from a donor are infused into the patient they may help the patient’s bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted cells from a donor can make an immune response against the body’s normal cells. Removing the T cells from the donor cells before transplant may stop this from happening. Giving an infusion of the donor’s T cells (donor lymphocyte infusion) later may help the patient’s immune system see any remaining cancer cells as not belonging in the patient’s body and destroy them (called graft-versus-tumor effect)

DISEASE(S): Extranodal Marginal Zone B-cell Lymphoma Of Mucosa-associated Lymphoid Tissue,Recurrent Grade 3 Follicular Lymphoma,Lymphoma, Large B-cell, Diffuse,Adult Grade Iii Lymphomatoid Granulomatosis,Lymphoma, Large-cell, Immunoblastic,Lymphoproliferative Disorders,Waldenström Macroglobulinemia,Recurrent Adult Lymphoblastic Lymphoma,Small Intestine Lymphoma,Recurrent Grade 1 Follicular Lymphoma,Refractory Hairy Cell Leukemia,Testicular Lymphoma,Splenic Marginal Zone Lymphoma,Leukemia, Hairy Cell,Lymphoma, Mantle-cell,Recurrent Adult Immunoblastic Large Cell Lymphoma,Recurrent Adult Burkitt Lymphoma,Lymphomatoid Granulomatosis,Lymphoma, Extranodal Nk-t-cell,Plasmablastic Lymphoma,Precursor Cell Lymphoblastic Leukemia-lymphoma,Lymphoma, B-cell, Marginal Zone,Burkitt Lymphoma,Lymphoma,Recurrent Adult Diffuse Small Cleaved Cell Lymphoma,Post-transplant Lymphoproliferative Disorder,Nodal Marginal Zone B-cell Lymphoma,Recurrent Small Lymphocytic Lymphoma,Recurrent Adult Diffuse Mixed Cell Lymphoma,Recurrent Marginal Zone Lymphoma,Recurrent Grade 2 Follicular Lymphoma,Lymphoma, Follicular,Waldenstrom Macroglobulinemia,Recurrent Adult Grade Iii Lymphomatoid Granulomatosis,Lymphoma, Non-hodgkin,Recurrent Adult Diffuse Large Cell Lymphoma,Intraocular Lymphoma,Leukemia, Lymphocytic, Chronic, B-cell,Lymphoma, B-cell,Cutaneous B-cell Non-hodgkin Lymphoma,Recurrent Mantle Cell Lymphoma

PROVIDER: 2141916 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR