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Sirolimus, Tacrolimus, and Antithymocyte Globulin in Preventing Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant For Hematological Cancer

ABSTRACT: RATIONALE: Giving chemotherapy and total-body irradiation before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells. It also stops the patient’s immune system from rejecting the donor’s stem cells. The donated stem cells may replace the patient’s immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Sometimes the transplanted cells from a donor can also make an immune response against the body’s normal cells. Giving tacrolimus, sirolimus, antithymocyte globulin, and methotrexate before and after transplant may stop this from happening. PURPOSE: This phase II trial is studying how well sirolimus, tacrolimus, and antithymocyte globulin work in preventing graft-versus-host disease in patients undergoing a donor stem cell transplant for hematological cancer .

DISEASE(S): Primary Myelofibrosis,Myeloproliferative Disorders,Myelodysplastic-myeloproliferative Diseases,Leukemia,Graft Versus Host Disease,Secondary Myelofibrosis,Angioimmunoblastic T-cell Lymphoma,Neoplasms,Neoplasm Metastasis,Myelodysplastic/myeloproliferative Neoplasms,Plasmacytoma,Multiple Myeloma,Myelodysplastic Syndromes,Multiple Myeloma And Plasma Cell Neoplasm,Preleukemia,Precancerous Condition,Burkitt Lymphoma,Small Intestine Cancer,Lymphoma,Infection,Graft Vs Host Disease,Precancerous Conditions,Intestinal Neoplasms,Neoplasms, Plasma Cell,Chronic Myeloproliferative Disorders

PROVIDER: 2048717 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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