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Mechanistic Model-Guided Study of Embryonic Morphogenesis

ABSTRACT: We utilize a finite element model of implantation mechanics to guide the in vitro micropatterning human embryonic stem cells to simulate in vivo stress gradients that form during development. Micropatterned stem cells showed early formation of GATA4+/SOX17+ primitive endoderm due to migration toward regions of high stress, while NANOG+/OCT4+ epiblast was retained in regions of low stress under spontaneous differentiation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE123074 | GEO | 2018/11/29

REPOSITORIES: GEO

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