Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MRNA expression profile in WT and ZNF598 knockout HeLa cells stimulated with short poly I:C

ABSTRACT: mRNA expression profiles were compared between wild-type and ZNF598 knockout cells in the presence or absence of a RIG-I ligand, short poly I:C.

ORGANISM(S): Homo sapiens

PROVIDER: GSE130370 | GEO | 2019/07/30

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

mRNA expression profile in WT and ZNF598 knockout HeLa cells stimulated with short poly I:C

Project description:mRNA expression profile in WT and ZNF598 knockout HeLa cells stimulated with short poly I:C

| PRJNA539929 | ENA

mRNA expression profile in LGP2 and LGP2-4KR transgenic (Tg) HEK293 cells stimulated with short poly I:C

Project description:mRNA expression profiles were compared between wild-type LGP2 and four amino acid replacement LGP2 (LGP2-4KR) cells in the presence or absence of a RIG-I ligand, short poly I:C.

2022-06-07 | GSE176363 | GEO

Global alteration of transcript decay rates upon ZNF598 knockdown

Project description:We calculated half-life of transcripts in HEK293T cells expressing control or ZNF598-targeting shRNA.

2024-07-11 | GSE233374 | GEO

A role for ZNF598 in post-transcriptional gene regulation

Project description:Transcriptomic changes in U2OS cells upon depletion of the RNA-binding protein ZNF598 were analyzed in non-treated and IL-1 beta treated cells in comparison to control U2OS cells

2019-03-26 | GSE116126 | GEO

Poly(A)-ClickSeq resolves CF25-mediated alternative poly-adenylation, HeLa

Project description:Poly(A)-ClickSeq is a new methodology for the sequencing of the 3'UTR/poly(A) tail junction of RNA. We analysed both wild-type and CF25Im knock-down HeLa cells in culture using Poly(A)-ClickSeq to find the distribution of poly(A) sites in these samples and determine the role of CF25Im in poly(A) site selection (alternative poly-adenylation, APA).

2017-05-02 | GSE94950 | GEO

Translation of zinc finger domains induces ribosome collision and Znf598-dependent mRNA decay in zebrafish [Ribo-seq]

Project description:Quality control of translation is crucial for maintaining cellular and organismal homeostasis. Obstacles in translation elongation induce ribosome collision, which is monitored by multiple sensor mechanisms in eukaryotes. The E3 ubiquitin ligase Znf598 recognizes collided ribosomes, triggering ribosome-associated quality control (RQC) to rescue stalled ribosomes and no-go decay (NGD) to degrade stall-prone mRNAs. However, the impact of RQC and NGD on maintaining the translational homeostasis of endogenous mRNAs has remained unclear. In this study, we investigated the endogenous substrate mRNAs of NGD during the maternal-to-zygotic transition (MZT) of zebrafish development. RNA-Seq analysis of zebrafish znf598 mutant embryos revealed that Znf598 downregulates mRNAs encoding the C2H2-type zinc finger domain (C2H2-ZF) during the MZT. Reporter assays and disome profiling indicated that ribosomes stall and collide while translating tandem C2H2-ZFs, leading to mRNA degradation by Znf598. Our results suggest that NGD maintains the quality of the translatome by mitigating the risk of ribosome collision at the abundantly present C2H2-ZF sequences in the vertebrate genome.

2024-10-03 | GSE236144 | GEO

Translation of zinc finger domains induces ribosome collision and Znf598-dependent mRNA decay in zebrafish [RNA-seq]

2024-10-03 | GSE236143 | GEO

ZNF598 substrate identification

Project description:This study uses ubiquitin proteomics to identify substrates for the ZNF598 ubiquitin ligase

2016-12-08 | MSV000080390 | MassIVE

Next Generation Sequencing Facilitates Quantitative Analysis of Genes expression profiles in ZNFX1 overexpression in Rig-I-/- cells with or without poly I:C stimulation

Project description:Genes expression profiles in ZNFX1 overexpression in Rig-I-/- cells with or without poly I:C stimulation in A549 cells.

2019-08-30 | GSE132892 | GEO

Differential RNASeq of human bronchial epithelial cells stimulated with RIG-I ligand SLR14

Project description:The purpose of this study was to assess transcriptome changes in primary human airway epithelial cells following stimulation with RIG-I ligand.

2018-08-17 | GSE107897 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data