Identification of pathways and transcription factors relevant to gut inflammation and anti-inflammatory probiotics
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ABSTRACT: Using Affymetrix data analysis, important signalling pathways and transcription factors relevant to gut inflammation and anti-inflammatory action of probiotics were identified using the clinically validated probiotic VSL#3 and the IL10-knockout mouse, an animal model for inflammatory bowel disease. VSL#3 increased expression of genes involved in PPAR signalling and metabolism of xenobiotics and decreased expression of genes involved in immune response/inflammatory response.
ORGANISM(S): Mus musculus
PROVIDER: GSE13819 | GEO | 2009/07/29
SECONDARY ACCESSION(S): PRJNA110595
REPOSITORIES: GEO
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