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Identification of circulating microRNA signatures as potential biomarkers in the serum of elk infected with chronic wasting disease

ABSTRACT: Purpose: Idenfication of microRNA biomarkers of Chronic wasting disease in serum from infected elk Methods: Illumina next generation was used to profile abundance of serum miRNA in elk naturally infected with chronic wasting disease and Hamsters experimentally infected with the 263K scrapie prion strains Results: A signature of 21 miRNAs with diagnostic potential was found to be altered in abundance in serum from CWD infected elk. Of these, 6 were similarily altered in the serum from the 263K infected hamsters Conclusion: These altered miRNA signatures may serve as the basis for non-invasive diagnostic assays for chronic wasting disease and may shed light on the pathogenesis of prion infection

ORGANISM(S): Cervus canadensis Mesocricetus auratus

PROVIDER: GSE139501 | GEO | 2019/10/29

REPOSITORIES: GEO

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