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Expression data from liver tissue from Spontaneously hypertensive rat (SHR) and its minimal congenic strain PD5 on standart labaratory chow and after dexamethasone challenge

ABSTRACT: The dissection of genetic components of metabolic syndrome is currently one of the most important research topics. Plzf gene is a promising candidate gene. Previously, we described minimal congenic strain PD5 derived from spontaneously hypertensive rat (SHR), containing congenic segment of polydactylous (PD/Cub) origin with a 2964bp intronic deletion within Plzf gene and displaying attenuated features of metabolic syndrome. To unravel the genetic background responsible for the observed of this phenotype in PD5 we compared liver transcriptomes and physiologic parameters between SHR and PD5 strains without intervention and after dexamethasone administration.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE234984 | GEO | 2024/09/28

REPOSITORIES: GEO

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