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Single-cell RNA and ATAC sequencing revealed distinct molecular characteristics of B cells in systemic lupus erythematosus and primary Sjogren's syndrome (scATAC-Seq)

ABSTRACT: Objective: Autoimmune diseases (ADs), such as systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS), are complex diseases with poorly understood pathogenetic mechanisms. Epigenetic changes are crucial regulatory elements in B-cell differentiation, and disruptions to these mechanisms may contribute to the development of ADs. We hypothesized that shared mechanisms may contribute to the pathogenesis of SLE and pSS by disrupting transcriptional circuits.

ORGANISM(S): Homo sapiens

PROVIDER: GSE239458 | GEO | 2024/07/05

REPOSITORIES: GEO

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Single-cell RNA and ATAC sequencing revealed distinct molecular characteristics of B cells in systemic lupus erythematosus and primary Sjogren's syndrome (scRNA-Seq)

Project description:Objective: Autoimmune diseases (ADs), such as systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS), are complex diseases with poorly understood pathogenetic mechanisms. Epigenetic changes are crucial regulatory elements in B-cell differentiation, and disruptions to these mechanisms may contribute to the development of ADs. We hypothesized that shared mechanisms may contribute to the pathogenesis of SLE and pSS by disrupting transcriptional circuits.

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