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CoMtb alters the immune landscape following Mtb infection [C3H scRNAseq]

ABSTRACT: To gain further insights into lesion development and effects of CoMtb on immune responses during infection. we performed single-cell RNA sequencing (scRNAseq) and flow cytometry analysis of lungs from Mtb-infected animals with and without CoMtb immediately pre-infection and at 10. 17 and 34 days after CD infection. We found that CoMtb induces rapid recruitment and activation of T cells. macrophage activation. and diminished late neutrophil responses.

ORGANISM(S): Mus musculus

PROVIDER: GSE265843 | GEO | 2024/04/29

REPOSITORIES: GEO

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