Transcriptomics

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CoMtb alters the immune landscape following Mtb infection [B6 scSCRNAseq]

ABSTRACT: To characterize the influence of CoMtb on immune responses during infection, we performed single-cell RNA sequencing (scRNAseq) and flow cytometry analysis of lungs from Mtb-infected C57Bl/6 mice with and without CoMtb immediately pre-infection and at 10, 17 and 34 days after conventional dose (50-100 CFU) Mtb infection. We found that CoMtb induces rapid recruitment and activation of T cells, macrophage, and diminished late neutrophil responses.

ORGANISM(S): Mus musculus

PROVIDER: GSE266233 | GEO | 2024/06/18

REPOSITORIES: GEO

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