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CoMtb alters the immune landscape following Mtb infection [B6 scSCRNAseq]

ABSTRACT: CoMtb alters the immune landscape following Mtb infection [B6 scSCRNAseq]

PROVIDER: PRJNA1106428 | ENA |

REPOSITORIES: ENA

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CoMtb alters the immune landscape following Mtb infection [B6 Sp140-/- scRNA-Seq]

Project description:To gain further insights into lesion development and effects of CoMtb on immune responses during infection. we performed single-cell RNA sequencing (scRNAseq) and flow cytometry analysis of lungs from Mtb-infected B6 Sp140-/- mice with and without CoMtb at 10 days after CD infection. We found that CoMtb induces rapid recruitment and activation of T cells. macrophage activation. and diminished late neutrophil responses.

2024-06-18 | GSE266432 | GEO

CoMtb alters the immune landscape following Mtb infection [B6 scSCRNAseq]

Project description:To characterize the influence of CoMtb on immune responses during infection, we performed single-cell RNA sequencing (scRNAseq) and flow cytometry analysis of lungs from Mtb-infected C57Bl/6 mice with and without CoMtb immediately pre-infection and at 10, 17 and 34 days after conventional dose (50-100 CFU) Mtb infection. We found that CoMtb induces rapid recruitment and activation of T cells, macrophage, and diminished late neutrophil responses.

2024-06-18 | GSE266233 | GEO

CoMtb alters the immune landscape following Mtb infection [B6 Sp140-/- scRNA-Seq]

Project description:CoMtb alters the immune landscape following Mtb infection [B6 Sp140-/- scRNA-Seq]

| PRJNA1107174 | ENA

CoMtb alters the immune landscape following Mtb infection [C3H scRNAseq]

Project description:To gain further insights into lesion development and effects of CoMtb on immune responses during infection. we performed single-cell RNA sequencing (scRNAseq) and flow cytometry analysis of lungs from Mtb-infected animals with and without CoMtb immediately pre-infection and at 10. 17 and 34 days after CD infection. We found that CoMtb induces rapid recruitment and activation of T cells. macrophage activation. and diminished late neutrophil responses.

2024-04-29 | GSE265843 | GEO

CoMtb alters the immune landscape following Mtb infection [C3H scRNAseq]

Project description:CoMtb alters the immune landscape following Mtb infection [C3H scRNAseq]

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Single-cell gene expression analysis of pulmonary immune cells from BCG-vaccinated and CoMtb mice [scRNAseq]

Project description:The aim of this study was to measure effect of BCG vaccination or contained Mtb infection (CoMTB) on the expression profile of pulmonary immune cells.

2023-11-30 | GSE212204 | GEO

Gene expression analysis of alveolar macrophages from BCG-vaccinated and CoMtb mice stimulated ex vivo [exvivoRNAseq]

Project description:The aim of this study was to measure the response of alveolar macrophages (AMs) from BCG-vaccinated mice and mice with CoMtb to LPS, PAM3CSK4, and Mtb stimulation ex vivo.

2023-11-30 | GSE212203 | GEO

Discerning the roles of key cytokine signaling pathways in DR Mtb infection [dataset1]

Project description:We have found that drug-resistant (DR) Mtb infection alters the host pathogen interactions thought to occur during drug-sensitive (DS) Mtb infection. Recent data suggests that lack of both, Type I and IL-1, signaling pathways leads to susceptibility to infection to DR Mtb infection. To understand the pathways involved in maintaining control of DR Mtb infection, we are sequencing the bulk lung cells early in infection.

2024-04-03 | GSE249400 | GEO

Discerning the roles of key cytokine signaling pathways in DS HN878 Mtb infection [dataset2]

Project description:We have found that drug-resistant (DR) Mtb infection alters the host pathogen interactions thought to occur during drug-sensitive (DS) Mtb infection. Recent data suggests that lack of IL-1, but not Type I IFN, signaling pathways leads to susceptibility to infection to DR Mtb infection. To understand the pathways involved in maintaining control of DS Mtb infection, we are sequencing the bulk lung cells early in infection.

2024-04-03 | GSE249401 | GEO

Progression to Latent Infection Following Exposure to Mtb

Project description:These results were obtained in a controlled longitudinal experiment in which a group of rhesus macaques were exposed to a low dose of Mtb to study their progression to latent infection or active disease. Subsets of the animals were euthanized at scheduled time points, and granulomas taken from their lungs were assayed for gene expression. The clinical profiles associated with the animals following Mtb exposure revealed considerable variability, and we developed models for the disease trajectory for each subject using a Bayesian hierarchical B-spline approach. Disease severity estimates were derived from these fitted curves and included as covariates in linear models to identify genes significantly associated with disease progression. Our results demonstrate that the incorporation of clinical data increases the value of information extracted from the expression profiles and contributes to the identification of predictive biomarkers for TB susceptibility. Samples from 21 animals were included in this study. 18 rhesus macaques were exposed to Mtb and euthanisized according to a pre-defined schedule, and at least two granulomas were extracted from their lungs during necropsy. The remaining three animals were healthy controls and samples represent control lung tissues. The samples were arrayed using an extended loop design with animals grouped according to similar clinical profiles. Biological replication is provided in the form of at least two granuloma samples per animal.

2014-04-19 | E-GEOD-56919 | biostudies-arrayexpress

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