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Runx3 function in IL-2-activated splenic CD8+ T cells.

ABSTRACT: CD8+T cells are immune cells that recognize foreign antigens on infected and tumor cells, leading to cytokine-dependent expansion and activation of cytotoxicity towards the targets.

ORGANISM(S): Mus musculus

PROVIDER: GSE50121 | GEO | 2013/11/18

SECONDARY ACCESSION(S): PRJNA216117

REPOSITORIES: GEO

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Runx3 function in IL-2-activated splenic CD8+ T cells

Project description:CD8+T cells are immune cells that recognize foreign antigens on infected and tumor cells, leading to cytokine-dependent expansion and activation of cytotoxicity towards the targets. To identify Runx3 regulated genes, CD8+ T cells were isolated from spleen of WT and Runx3-/- mice . Six samples (3 WT and 3 Runx3-/-) of CD8+ T cells were separately obtained from individual mice, TCR activated and cultured for 4 days with IL-2.

2013-11-18 | E-GEOD-50121 | biostudies-arrayexpress

Runx3 function in CD8+ splenic T cells

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Runx3 function in splenic NK cells activated in vivo by IL-15.

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Project description:NK cells are innate immune cells that recognize and kill foreign, virally-infected and tumor cells without the need for prior immunization. NK expansion following viral infection is IL-2 or IL-15-dependent. To identify Runx3 responsive genes, NK cells were isolated from spleen of WT and Runx3-/- mice . Ten samples (5 WT and 5 Runx3-/-) of freshly isolated NK cells were separately obtained from individual mice. Cells were cultured for 7 days with IL-2 or IL-15.

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