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Runx3 function in splenic NK cells activated in vivo by IL-15.

ABSTRACT: NK cells are innate immune cells that recognize and kill foreign, virally-infected and tumor cells without the need for prior immunization. NK expansion following viral infection is IL-2 or IL-15-dependent.

ORGANISM(S): Mus musculus

PROVIDER: GSE50120 | GEO | 2014/01/22

SECONDARY ACCESSION(S): PRJNA216118

REPOSITORIES: GEO

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Runx3 function in splenic NK cells (IL-2 or IL-15)

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Runx3 function in splenic NK cells activated in vivo by IL-15.

Project description:NK cells are innate immune cells that recognize and kill foreign, virally-infected and tumor cells without the need for prior immunization. NK expansion following viral infection is IL-2 or IL-15-dependent. To identify Runx3 regulated genes, NK cells were isolated from spleen of IL15/Ra injected WT and Runx3-/- mice and sorted to obtain 3 subpopulations of immature (CD27) and mature (DP and CD11c) NK cells.

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