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Gene expression profile of fibroblasts derived from CS patient

ABSTRACT: As the causative gene for cockayne syndrome, CSB has a well-characerized function in transcription-coupled nucleotide excision repair. However, the complex neurological abnormalities that affect CS patients can not be simply explained by the DNA repair defects. CSB is also involved in RNAP II transcription regulation. This study characterizes the gene expression signatures affected by CSB protein. Using Nimblegen microarray we identified differentially expressed genes in human fibroblasts derived from CS patients as compared to CSB reconstituted cell lines (wild type).

ORGANISM(S): Homo sapiens

PROVIDER: GSE58068 | GEO | 2014/09/22

SECONDARY ACCESSION(S): PRJNA248791

REPOSITORIES: GEO

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Gene expression profiles of various CSB mutant cell lines

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