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Couzens_Hippo_interactome_set3_P86_VS5_VS6_June22_2013

ABSTRACT: Interaction proteomics; FLAG AP-MS. Supplementary files for the Hippo Interactome manuscript by Couzens et al. This dataset consists of 20 files (specificity of MOB1 vs MOB4 and okadaic acid time course). See "README" file and sample description in the "Methods and Protocols" folder.

PROVIDER: MSV000078446 | MassIVE | Sat Jun 22 00:00:00 BST 2013

REPOSITORIES: MassIVE

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Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

Couzens Amber L AL Knight James D R JD Kean Michelle J MJ Teo Guoci G Weiss Alexander A Dunham Wade H WH Lin Zhen-Yuan ZY Bagshaw Richard D RD Sicheri Frank F Pawson Tony T Wrana Jeffrey L JL Choi Hyungwon H Gingras Anne-Claude AC

Science signaling 20131119 302

The Hippo pathway regulates organ size and tissue homeostasis in response to multiple stimuli, including cell density and mechanotransduction. Pharmacological inhibition of phosphatases can also stimulate Hippo signaling in cell culture. We defined the Hippo protein-protein interaction network with and without inhibition of serine and threonine phosphatases by okadaic acid. We identified 749 protein interactions, including 599 previously unrecognized interactions, and demonstrated that several i ...[more]

PMID: 24255178

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