Proteomics

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Lambert_P82_VS6_ZMYND8_reader_APMS_BioID_01OCT2015

ABSTRACT: This submission contains the mass spectrometry files for the manuscript by Filippakopoulos and colleges that characterize ZMYND8 by AP-MS and BioID. This submission contains 56 DDA files for the following baits: empty 3XFLAG control, GFP-BirA-FLAG control, NLS-BirA-FLAG control, 3xFLAG-ZMYND8 and 3xFLAG-ZMYND8 N288F. Two biological replicates for every baits were analyzed by the standard Gingras lab BioID protocol and by a protocol optimized for chromatin associated baits (AP-MS). See the README file within "Methods and Protocols" and the accompanying File description. This dataset consists of 56 raw MS files, all acquired on a 5600 TripleTOF Raw files are deposited here in MassIVE. For questions, please contact Anne-Claude Gingras (gingras@lunenfeld.ca) or Jean-Philippe Lambert (lambert@lunenfeld.ca). Internal reference from the Gingras lab ProHits implementation: Project 82, Export versions VS6 (ZMYND8_reader)

OTHER RELATED OMICS DATASETS IN: PRJNA322323

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Anne-Claude Gingras 

PROVIDER: MSV000079336 | MassIVE | Thu Oct 01 13:40:00 BST 2015

REPOSITORIES: MassIVE

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Publications

Elucidation of interactions involving DNA and histone post-translational-modifications (PTMs) is essential for providing insights into complex biological functions. Reader assemblies connected by flexible linkages facilitate avidity and increase affinity; however, little is known about the contribution to the recognition process of multiple PTMs because of rigidity in the absence of conformational flexibility. Here, we resolve the crystal structure of the triple reader module (PHD-BRD-PWWP) of Z  ...[more]

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