Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro 2
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: Anne-Claude Gingras
PROVIDER: MSV000093202 | MassIVE | Thu Oct 26 09:32:00 BST 2023
SECONDARY ACCESSION(S): PXD046426
REPOSITORIES: MassIVE
Nature 20240320 8009
Targeted protein degradation and stabilization are promising therapeutic modalities because of their potency, versatility and their potential to expand the druggable target space<sup>1,2</sup>. However, only a few of the hundreds of E3 ligases and deubiquitinases in the human proteome have been harnessed for this purpose, which substantially limits the potential of the approach. Moreover, there may be other protein classes that could be exploited for protein stabilization or degradation<sup>3-5< ...[more]