Metabolomics

Dataset Information

0

Regulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage


ABSTRACT:

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regulatory elements activated in response to exercise remain obscure. Here, we have addressed the roles of Foxp3+CD4+ regulatory T cells (Tregs) in the healthful activities of exercise via immunologic, transcriptomic, histologic, metabolic and biochemical analyses of acute and chronic murine exercise models. Exercise rapidly induced expansion of the muscle Treg compartment, thereby guarding against over-exuberant production of interferon gamma and consequent metabolic disruptions, particularly mitochondrial aberrancies. Importantly, the performance-enhancing effects of exercise training were dampened in the absence of Tregs. Thus, exercise is a natural Treg booster with therapeutic potential in disease and aging contexts.

INSTRUMENT(S): Liquid Chromatography MS - negative - hilic

SUBMITTER: Birgitta Ryback 

PROVIDER: MTBLS8391 | MetaboLights | 2023-10-10

REPOSITORIES: MetaboLights

Dataset's files

Source:
Action DRS
MTBLS8391 Other
FILES Other
a_MTBLS8391_LC-MS_negative_hilic_metabolite_profiling.txt Txt
i_Investigation.txt Txt
m_MTBLS8391_LC-MS_negative_hilic_metabolite_profiling_v2_maf.tsv Tabular
Items per page:
1 - 5 of 6
altmetric image

Publications

Regulatory T cells shield muscle mitochondria from interferon-γ-mediated damage to promote the beneficial effects of exercise.

Langston P Kent PK   Sun Yizhi Y   Ryback Birgitta A BA   Mueller Amber L AL   Spiegelman Bruce M BM   Benoist Christophe C   Mathis Diane D  

Science immunology 20231103 89


Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia, and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. Although some effector mechanisms have been identified, regulatory elements activated in response to exercise remain obscure. Here, we have addressed the roles of Foxp3<sup>+</sup>CD4<sup>+</sup> regulatory T cells (T<sub>regs</sub>) in the healthful activitie  ...[more]

Similar Datasets

2023-08-01 | GSE220181 | GEO
2019-12-04 | MSV000084659 | MassIVE
| 2120409 | ecrin-mdr-crc
2019-11-19 | GSE140633 | GEO
2015-01-05 | E-GEOD-63625 | biostudies-arrayexpress
2014-12-11 | E-GEOD-62535 | biostudies-arrayexpress
2022-12-02 | MODEL2211070001 | BioModels
2022-11-28 | PXD038302 | Pride
2022-07-20 | MSV000089924 | MassIVE
2020-03-11 | E-MTAB-8861 | biostudies-arrayexpress