Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Heterogeneity of hematopoietic progenitors in adult mouse liver

ABSTRACT: Heterogeneity of hematopoietic progenitors in adult mouse liver

PROVIDER: PRJNA697914 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13577644_1.fastq.gz	Fastqsanger.gz
	SRR13577644_2.fastq.gz	Fastqsanger.gz
	SRR13577645_1.fastq.gz	Fastqsanger.gz
	SRR13577645_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 4 of 4

Similar Datasets

Heterogeneity of hematopoietic progenitors in adult mouse liver

Project description:To investigate whether liver-resident ILC1s could develop from local hematopoietic progenitors, we analyzed the phenotypic properties of liver CD45+Lin- progenitors. We found that the adult mouse liver contained Lin-Sca-1+Mac-1+ (LSM) hematopoietic progenitors derived from the fetal liver. This population included Lin-CD122+CD49a+ progenitors that could generate liver ILC1s but not conventional NK (cNK) cells. By performing single-cell RNA seq, we show the heterogeneous composition of these hematopoietic progenitors.

2021-03-26 | GSE165785 | GEO

Mass spectrometry analysis of mouse hematopoietic stem cells and their progenitors reveals differential expression within and between proteome and transcriptome throughout adult and aged hematopoiesis

Project description:mass spectrometry analysis of aged and adult hematopoietic stem cells, multipotent progenitors and oligopotent progenitors

2021-07-24 | PXD017442 | Pride

Quantitative secretome analysis of fetal and adult hematopoietic progenitors during leukemia initiation and its response to Fibulin and/or Fibronectin treatment.

Project description:We describe the proteomic composition of the secretome of fetal and adult hematopoietic progenitors during MLL-rearranged (MLLr) leukemia initiation as well as the pre-leukemic cells’ secretion response to the treatment with Fibulin (Fbln1) and/or Fibronectin (Fn1) using data-independent acquisition mass spectrometry analysis.

2024-04-02 | PXD049014 | Pride

Quantitative extracellular proteome analysis of fetal liver and adult bone marrow

Project description:We describe the proteomic composition of the extracellular environment of fetal and adult hematopoietic progenitors by data-independent acquisition mass spectrometry analysis.

2024-04-02 | PXD042251 | Pride

BLUEPRINT hematopoietic progenitors

Project description:BLUEPRINT hematopoietic progenitors

| PRJNA343828 | ENA

A Human Liver Cell Atlas reveals Heterogeneity and Epithelial Progenitors

Project description:A Human Liver Cell Atlas reveals Heterogeneity and Epithelial Progenitors

| PRJNA511895 | ENA

Single-cell sequencing of yolk sac and fetal liver hematopoietic progenitors

Project description:Single-cell sequencing of yolk sac and fetal liver hematopoietic progenitors

| PRJNA699610 | ENA

Developmental and molecular heterogeneity of mouse hematopoietic stem cells

Project description:This study aims to investigate the developmental and molecular heterogeneity of mouse hematopoietic stem cell (mHSC). The genome-wide transcriptomic heterogeneity in wildtype and Bcl11a deficient mHSC will be stuided by single-cell mRNA sequencing technology. Brief protocol:Adult mouse LSK HSC is harvested from femur and FACS purified by surface markers CD48-, CD150+. Single cell capture and cDNA preparation are performed by Fluidigm C1 microfluidic system according to manufacturer protocol. Library is prepared by Illumina Nextera XT kit.

2015-06-24 | E-ERAD-407 | biostudies-arrayexpress

Single-cell sequencing of yolk sac and fetal liver hematopoietic progenitors

Project description:Erythro-myeloid progenitors (EMP) and their progeny were labeled with YFP in mouse embryos using genetic fate mapping (constitutive Csf1r-iCre;Rosa26-eYFP or inducible Csf1r-MeriCreMer;Rosa26-eYFP injected at embryonic day E8.5 with 4-hydroxytamoxifen). EMP-derived progenitors (Lin- Kit+ YFP+) were sorted by FACS for single-cell transcriptomic analysis using the MARS-Seq approach. The purpose was to uncover heterogeneity and differentiation trajectories of EMP by comparing their transcriptional status at different developmental timepoints (E9.5, E10.5 and E12.5) and across niches (yolk sac and fetal liver).

2021-02-05 | GSE166223 | GEO

Symmetric self-renewal and dormancy define functional fetal liver hematopoietic stem cells at single cell resolution

Project description:Our study disclosed previously unrecognized heterogeneity in fetal liver (FL) hematopoietic stem cells (HSC), highlighting biosynthetic dormancy as a key to symmetric self-renewal of engraftable HSC and supports recent studies demonstrating distinct developmental origins for multipotent progenitors and HSC in definitive hematopoiesis.

2023-05-24 | GSE233031 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data