Dataset Information

Putamen proteme - Anatomo-proteomic characterization of human basal ganglia: focus on striatum and globus pallidus

ABSTRACT: In order to analyse the putamen proteome in a large-scale format, we used a multi-dimensional fractionation approach which combines isolation of anatomically-defined nuclei, and protein/peptide chromatographic fractionation strategies coupled to mass spectrometry.

INSTRUMENT(S): Q TRAP

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Disease Free

SUBMITTER: Enrique SantamarÃa

LAB HEAD: Enrique Santamaria

PROVIDER: PXD000749 | Pride | 2018-10-19

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Putamen.group.xml	Xml
	PutamenFDR.xlsx	Xlsx
	PutamenIEF10_109122013.wiff	Wiff
	PutamenIEF10_2091220131.wiff	Wiff
	PutamenIEF11_1Putamen29112013.wiff	Wiff

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Publications

Anatomo-proteomic characterization of human basal ganglia: focus on striatum and globus pallidus.

Fernández-Irigoyen Joaquín J Zelaya María Victoria MV Tuñon Teresa T Santamaría Enrique E

Molecular brain 20141118

<h4>Background</h4>The basal ganglia (BG) are a complex network of subcortical nuclei involved in the coordination and integration of the motor activity. Although these independent anatomical structures are functionally related, the proteome present in each isolated nucleus remains largely unexplored. In order to analyse the BG proteome in a large-scale format, we used a multi-dimensional fractionation approach which combines isolation of anatomically-defined nuclei, and protein/peptide chromato ...[more]

PMID: 25406675

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