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Global proteomic analysis of changes in the Caenorhabditis elegans proteome during Klebsiella pneumoniae infection

ABSTRACT: In this study, the changes in the global proteomics of C. elegans were analyzed by proteomics approach. The nematodes were exposed to K. pneumoniae for different time-points (12, 24 and 36 h) and the changes in the regulation were analyzed by employing mass spectrometry.

INSTRUMENT(S): AXIMA Performance MALDI-TOF/TOF

ORGANISM(S): Caenorhabditis Elegans

TISSUE(S): Whole Body

SUBMITTER: Arumugam Kamaladevi

LAB HEAD: Krishnaswamy Balamurugan

PROVIDER: PXD007151 | Pride | 2017-09-06

REPOSITORIES: Pride

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			Action	DRS
	A11_24h_88.run	Other
	A11_24h_88.xml	Xml
	A11_36h_274.run	Other
	A11_36h_274.xml	Xml
	A12_24h_293.run	Other

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Publications

Global Proteomics Revealed Klebsiella pneumoniae Induced Autophagy and Oxidative Stress in Caenorhabditis elegans by Inhibiting PI3K/AKT/mTOR Pathway during Infection.

Kamaladevi Arumugam A Balamurugan Krishnaswamy K

Frontiers in cellular and infection microbiology 20170906

The enterobacterium, Klebsiella pneumoniae invades the intestinal epithelium of humans by interfering with multiple host cell response. To uncover a system-level overview of host response during infection, we analyzed the global dynamics of protein profiling in Caenorhabditis elegans using quantitative proteomics approach. Comparison of protein samples of nematodes exposed to K. pneumoniae for 12, 24, and 36 h by 2DE revealed several changes in host proteome. A total of 266 ...[more]

PMID: 28932706

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