Dataset Information

Proteomic analysis of substantia nigra

ABSTRACT: Proteomic analysis of human substantia nigra using protein and peptide fractionations strategies coupled to nanoLC-MS/MS

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

SUBMITTER: Enrique SantamarÃa

LAB HEAD: Enrique Santamaria

PROVIDER: PXD001496 | Pride | 2015-08-17

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	041-SNETTAN-041-SuntanciaNegra26082014-14.wiff	Wiff
	041-SNETTAN-041-SuntanciaNegra26082014-14.wiff.scan	Wiff
	041-SNETTAN-041-SuntanciaNegra26082014-14.xml	Xml
	041-SNETTAN-041-SuntanciaNegra26082014-14_PeptideSummary.txt	Txt
	041-SNETTAN-041-SuntanciaNegra26082014-14_ProteinSummary.txt	Txt

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Publications

New insights into the human brain proteome: Protein expression profiling of deep brain stimulation target areas.

Fernández-Irigoyen Joaquín J Zelaya María Victoria MV Perez-Valderrama Estela E Santamaría Enrique E

Journal of proteomics 20150404 Pt B

Deep brain stimulation (DBS) is a neurosurgical procedure that provides therapeutic benefits for movement and affective disorders. The nucleus basalis of Meynert (NBM) and substantia nigra (SN) are considered target areas to apply DBS. Even though the degeneration of NBM and SN underlies the cognitive decline observed in neurological diseases, the protein knowledge derived from both areas is scarce. We have characterized the proteome present in both subcortical brain areas using the Triple TOF 5 ...[more]

PMID: 25845585

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