Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Kidney
SUBMITTER: Giulia Calloni
LAB HEAD: R. Martin Vabulas
PROVIDER: PXD008171 | Pride | 2018-04-26
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 46 |
Lang Wei-Han WH Lang Wei-Han WH Calloni Giulia G Vabulas R Martin RM
Journal of proteome research 20180425 5
C-terminal polylysine (PL) can be synthesized from the polyadenine tail of prematurely cleaved mRNAs or when a read-though of a stop codon happens. Due to the highly positive charge, PL stalls in the electrostatically negative ribosomal exit channel. The stalled polypeptide recruits the Ribosome-associated quality control (RQC) complex which processes and extracts the nascent chain. Dysfunction of the RQC leads to the accumulation of PL-tagged proteins, induction of a stress response, and cellul ...[more]