Dataset Information

Quantitative analysis of large-scale proteomic changes in LPS-activated monocyte-derived dendritic cells: A SWATH-MS study

ABSTRACT: Determination of global alterations in monocyte-derived dendritic cells in response to stimulation with lipopolysaccharide using SWATH-MS to provide insight into cellular mechanism driving dendritic cell maturation

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Dendritic Cell, Blood

SUBMITTER: Silvia Synowsky

LAB HEAD: Dr Alan James Stewart

PROVIDER: PXD008898 | Pride | 2019-03-18

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	ConditionPlot.pdf	Pdf
	Dendritic_cell_library.group	Other
	Dendritic_cell_library.group.xml	Xml
	Dendritic_cell_library__FDR.xlsx	Xlsx
	ProfilePlot.pdf	Pdf

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Quantitative proteomic changes in LPS-activated monocyte-derived dendritic cells: A SWATH-MS study.

Arya Swati S Wiatrek-Moumoulidis Dagmara D Synowsky Silvia A SA Shirran Sally L SL Botting Catherine H CH Powis Simon J SJ Stewart Alan J AJ

Scientific reports 20190313 1

Dendritic cells are key immune cells that respond to pathogens and co-ordinate many innate and adaptive immune responses. Quantitative mass spectrometry using Sequential Window Acquisition of all THeoretical fragment-ion spectra-Mass Spectrometry (SWATH-MS) was performed here to determine the global alterations in monocyte-derived dendritic cells (moDCs) in response to stimulation with lipopolysaccharide (LPS). A moDC library of 4,666 proteins was generated and proteins were quantified at 0, 6 a ...[more]

PMID: 30867486

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