Proteomics

Dataset Information

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Thermal proteome profiling of anti-HEV compound

ABSTRACT: We performed thermal proteome profiling (TPP) to identify targets of a new anti hepatitis E virus compound.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human) Hepatitis E Virus Type 1

SUBMITTER: Andre Mateus  

LAB HEAD: Alexander Ploss

PROVIDER: PXD014485 | Pride | 2021-01-04

REPOSITORIES: Pride

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Dataset's files

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Bert_S1607_IB_Ploss_replicon_2DTPP_cpdC_T11T12_R1_F1.raw Raw
Bert_S1607_IB_Ploss_replicon_2DTPP_cpdC_T11T12_R1_F2.raw Raw
Bert_S1607_IB_Ploss_replicon_2DTPP_cpdC_T11T12_R1_F3.raw Raw
Bert_S1607_IB_Ploss_replicon_2DTPP_cpdC_T11T12_R1_F4.raw Raw
Bert_S1607_IB_Ploss_replicon_2DTPP_cpdC_T11T12_R1_F5.raw Raw
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Publications

Hepatitis E virus (HEV) causes 14 million infections and 60,000 deaths per year globally, with immunocompromised persons and pregnant women experiencing severe symptoms. Although ribavirin can be used to treat chronic hepatitis E, toxicity in pregnant patients and the emergence of resistant strains are major concerns. Therefore there is an imminent need for effective HEV antiviral agents. The aims of this study were to develop a drug screening platform and to discover novel approaches to targeti  ...[more]

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