Proteomics

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Thermal proteome profiling in Escherichia coli

ABSTRACT: We used thermal proteome profiling (TPP) to study the thermostability of Escherichia coli strains in the presence of duloxetine.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Escherichia Coli

SUBMITTER: Andre Mateus  

LAB HEAD: Kiran Patil

PROVIDER: PXD016062 | Pride | 2021-07-01

REPOSITORIES: Pride

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Bert_S1613_AM_2DTPP_Ecoli_ED1a_wholecell_duloxetine_T1T2_n1_R1_F1.raw Raw
Bert_S1613_AM_2DTPP_Ecoli_ED1a_wholecell_duloxetine_T1T2_n1_R1_F2.raw Raw
Bert_S1613_AM_2DTPP_Ecoli_ED1a_wholecell_duloxetine_T1T2_n1_R1_F3.raw Raw
Bert_S1613_AM_2DTPP_Ecoli_ED1a_wholecell_duloxetine_T1T2_n1_R1_F4.raw Raw
Bert_S1613_AM_2DTPP_Ecoli_ED1a_wholecell_duloxetine_T1T2_n1_R1_F5.raw Raw
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Publications

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However, the systematic mapping of the interactions between drugs and bacteria has only started recently<sup>1</sup> and the main underlying mechanism proposed is the chemical transformation of drugs by microorganisms (biotransformation). Here we investigated the depletion of 15 structurally diverse drugs by 25 representative strains of gut bacteria. This revealed 70 bacteria-drug interactions, 29 of which had n  ...[more]

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