Proteomics

Dataset Information

0

Characterization of PITH domain-containing protein 1 (C1orf128) functionality in olfactory metabolism

ABSTRACT: Taking into account the relevance of the smell sense in the early diagnosis of neurodegenerative diseases, we have analyzed the expression profile of the dark proteome across public proteomic and transcriptomic data derived from primary olfactory areas such as olfactory bulb (OB) and cleft mucus as well as from specific brain/OB cell linages. In this study, we have used an experimental workflow combining neuropathological diagnosis, co-regulation maps, physical and functional interaction data, transgenic models, intracellular and extracellular proteomics and immunohistochemical and biochemical approaches to partially decipher the UPE1 PITHD1 function in olfactory metabolism.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Mikel Azkargorta  

LAB HEAD: Felix Elortza

PROVIDER: PXD018784 | Pride | 2020-11-19

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
SPROT_Human_2020_04.fasta Fasta
TMT_Sample1+2+3_Slot1-10_2-29-2020_7114.pride.mgf.gz Mgf
TMT_Sample10_Slot1-38_3-1-2020_7138.d.7z Other
TMT_Sample10_Slot1-38_3-1-2020_7138.mgf Mgf
TMT_Sample10_Slot1-38_3-1-2020_7138.pride.mgf.gz Mgf
Items per page:
1 - 5 of 78
altmetric image

Publications

Smelling the Dark Proteome: Functional Characterization of PITH Domain-Containing Protein 1 (C1orf128) in Olfactory Metabolism.

Lachén-Montes Mercedes M   Mendizuri Naroa N   Ausín Karina K   Pérez-Mediavilla Alberto A   Azkargorta Mikel M   Iloro Ibon I   Elortza Felix F   Kondo Hiroyuki H   Ohigashi Izumi I   Ferrer Isidre I   de la Torre Rafael R   Robledo Patricia P   Fernández-Irigoyen Joaquín J   Santamaría Enrique E  

Journal of proteome research 20201113 12

The Human Proteome Project (HPP) consortium aims to functionally characterize the dark proteome. On the basis of the relevance of olfaction in early neurodegeneration, we have analyzed the dark proteome using data mining in public resources and omics data sets derived from the human olfactory system. Multiple dark proteins localize at synaptic terminals and may be involved in amyloidopathies such as Alzheimer's disease (AD). We have characterized the dark PITH domain-containing protein 1 (PITHD1  ...[more]

Similar Datasets

Proteomics Alpha-Synuclein pathology and reduced neurogenesis in the olfactory system affect olfaction in a mouse model of Parkinson's disease
2023-01-13 | PXD039396 | Pride
Transcriptomics Comparative Gene Expression Profiling of Olfactory Ensheathing Cells from Olfactory Bulb and Olfactory Mucosa
2009-12-02 | GSE19250 | GEO
Proteomics Olfactory proteomics in amyotrophic lateral sclerosis
2021-09-09 | PXD021630 | Pride
Transcriptomics olfactory bulb from control mouse and a mouse with developmentally-induced olfactory bulb degeneration
2023-09-04 | GSE241951 | GEO
Proteomics Olfactory bulb proteomics in human Alzheimer's disease
2018-01-16 | PXD005319 | Pride
Transcriptomics Next Generation Sequencing Facilitates Quantitative Analysis of Mock/SARS-CoV-2 Infected humanized ACE2 Mice Olfactory Epithelium and Olfactory Bulb Transcriptomes
2021-07-12 | GSE173186 | GEO
Proteomics proteomics of PITHD1-deficient mice
2020-11-19 | PXD021634 | Pride
Transcriptomics Pathological consequences of chronic olfactory inflammation on neurite morphology of olfactory bulb projection neurons
2022-04-06 | GSE185945 | GEO
Transcriptomics Progressive modulation of the human olfactory bulb transcriptome during Alzheimer's disease evolution: novel insights into the olfactory signaling across proteinopathies
2017-11-01 | GSE93885 | GEO
Transcriptomics Transcriptomics in olfactory cells transfected with SARS-CoV-2 structural proteins
2022-09-28 | GSE182849 | GEO