Dataset Information

Can Scoliotic Discs be Controls for Molecular Studies in Intervertebral Disc Research?- Insights from Proteomics.

ABSTRACT: Research on disc degeneration has been heterogeneous in their use of control discs used for comparison with diseased discs. Discs from scoliosis, cadavers and voluntary organ donors are the common controls used in intervertebral disc research. In order to find out the ideal control among these discs, the characters of scoliotic discs and discs from MRI normal voluntary organ donors controls used in disc research has been analysed using proteomics and to establish 'True Controls' that can be utilized for future Intervertebral disc (IVD) research.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Chondrocyte, Nucleus Pulposus, Notochordal Cell

DISEASE(S): Degenerative Disc Disease

SUBMITTER: Chitraa Tangavel

LAB HEAD: Dr Chitraa Tangavel

PROVIDER: PXD018968 | Pride | 2022-06-09

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	CT_T052_NP_S1_P1_1.mgf	Mgf
	CT_T052_NP_S1_P1_1.mzML	Mzml
	CT_T052_NP_S1_P1_1.mzid.gz	Mzid
	CT_T052_NP_S1_P1_1.pride.mgf.gz	Mgf
	CT_T052_NP_S1_P1_1.pride.mztab.gz	Mztab

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Publications

Can Scoliotic Discs Be Controls for Molecular Studies in Intervertebral Disc Research? Insights From Proteomics.

Rajasekaran S S Tangavel Chitraa C Anand K S Sri Vijay KSSV Soundararajan Dilip Chand Raja DCR Nayagam Sharon Miracle SM Sunmathi R R Raveendran M M Shetty Ajoy Prasad AP Kanna Rishi Mugesh RM Pushpa B T BT

Global spine journal 20200918 4

<h4>Study design</h4>Proteomic analysis of human intervertebral discs.<h4>Objectives</h4>To compare the characters of scoliotic discs and discs from magnetic resonance imaging (MRI)-normal voluntary organ donors controls used in disc research employing proteomics and establish "true controls" that can be utilized for future intervertebral disc (IVD) research.<h4>Methods</h4>Eight MRI-normal discs from 8 brain-dead voluntary organ donors (ND) and 8 scoliotic discs (SD) from 3 patients who underwe ...[more]

PMID: 32945197

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