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SIRT3 interactions and mitochondrial proteome during HCMV infection

ABSTRACT: SIRT3 has been shown to inhibit HCMV infection, but the mechanism under the antiviral effect is not clear. To identify the mediator of SIRT3 antiviral function, we aim to identify and quantify SIRT3 interactions during HCMV infection. A set of large-scale IPs were performed to determine the specific interactions with SIRT3 during infection, while small-scale IPs were conducted to determine the temporal interactions over the life cycle of infection. The mitochondrial proteome was used to characterize the changes of protein abundances after infection, and it was used for the normalization of acetylation.

INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung, Fibroblast

SUBMITTER: Xinlei Sheng

LAB HEAD: Ileana M. Cristea

PROVIDER: PXD018995 | Pride | 2021-04-01

REPOSITORIES: Pride

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			Action	DRS
	20170304_mito_proteome_HCMV_24hpi.msf	Msf
	20170304_mito_proteome_HCMV_24hpi.raw	Raw
	20170304_mito_proteome_HCMV_48hpi.msf	Msf
	20170304_mito_proteome_HCMV_48hpi.raw	Raw
	20170304_mito_proteome_HCMV_72hpi.msf	Msf

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