Proteomics

Dataset Information

0

Proteomic Analysis of Mkrn3 WT vs KO mouse brain


ABSTRACT: Mutations in the E3 ubiquitin ligase Mkrn3 are associated with precocious puberty in humans. In order to determine the targets of Mkrn3, we performed a TMT-based proteomic analysis of Mkrn3 WT vs KO mouse brains.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

DISEASE(S): Central Precocious Puberty

SUBMITTER: Brandon Gassaway  

LAB HEAD: Steven Gygi

PROVIDER: PXD027220 | Pride | 2023-07-20

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
m18338.raw Raw
m18338_PP_Comet_Rerun.mzIdentML Mzid
m18338_PP_Comet_Rerun.mzXML Mzxml
m18339.raw Raw
m18339_PP_Comet_Rerun.mzIdentML Mzid
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Publications


Makorin ring finger protein 3 (MKRN3) was identified as an inhibitor of puberty initiation with the report of loss-of-function mutations in association with central precocious puberty. Consistent with this inhibitory role, a prepubertal decrease in Mkrn3 expression was observed in the mouse hypothalamus. Here, we investigated the mechanisms of action of MKRN3 in the central regulation of puberty onset. We showed that MKRN3 deletion in hypothalamic neurons derived from human induced pluripotent s  ...[more]

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