Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
DISEASE(S): Central Precocious Puberty
SUBMITTER: Brandon Gassaway
LAB HEAD: Steven Gygi
PROVIDER: PXD027220 | Pride | 2023-07-20
REPOSITORIES: Pride
Action | DRS | |||
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m18338.raw | Raw | |||
m18338_PP_Comet_Rerun.mzIdentML | Mzid | |||
m18338_PP_Comet_Rerun.mzXML | Mzxml | |||
m18339.raw | Raw | |||
m18339_PP_Comet_Rerun.mzIdentML | Mzid |
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JCI insight 20230424 8
Makorin ring finger protein 3 (MKRN3) was identified as an inhibitor of puberty initiation with the report of loss-of-function mutations in association with central precocious puberty. Consistent with this inhibitory role, a prepubertal decrease in Mkrn3 expression was observed in the mouse hypothalamus. Here, we investigated the mechanisms of action of MKRN3 in the central regulation of puberty onset. We showed that MKRN3 deletion in hypothalamic neurons derived from human induced pluripotent s ...[more]