Proteomics

Dataset Information

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Receptor identification of Cyr61 on hunan colorectal cancer cell by LC-MS

ABSTRACT: To identify the unknown receptor, we extracted the membranous proteins from HCT8 cells treated with rCyr61.Then the proteins were subjected to mass spectrometry

INSTRUMENT(S): LTQ

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Colon

DISEASE(S): Colon Cancer

SUBMITTER: Zhenxing Liang  

LAB HEAD: Ping Lan

PROVIDER: PXD019954 | Pride | 2022-02-15

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Cyr61.mgf Mgf
Cyr61.raw Raw
IgG.group Other
IgG.mgf Mgf
IgG.raw Raw
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Publications

Cyr61 from adipose-derived stem cells promotes colorectal cancer metastasis and vasculogenic mimicry formation via integrin α<sub>V</sub> β<sub>5</sub>.

Liang Zhenxing Z   Liu Huashan H   Zhang Yunfeng Y   Xiong Li L   Zeng Ziwei Z   He Xiaowen X   Wang Fengwei F   Wu Xianrui X   Lan Ping P  

Molecular oncology 20210601 12

Adipose-derived stem cells (ADSCs) play a vital role in colorectal cancer (CRC) progression, but the mechanism remains largely unknown. Herein, we found that ADSCs isolated from CRC patients produced more cysteine-rich 61 (Cyr61) than those from healthy donors, and the elevated serum Cyr61 levels were associated with advanced TNM stages. Moreover, serum Cyr61 displayed a better diagnostic value for CRC compared to carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9). Mechanistically,  ...[more]

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