Dataset Information
Identification of a novel protein circINSIG1-121 in hunan colorectal cancer cell by LC-MS
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Colon
DISEASE(S): Colon Cancer
SUBMITTER: 
Zhenxing Liang
LAB HEAD: Li Xiong
PROVIDER: PXD037292 | Pride | 2023-05-10
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| F003380.csv | Csv | |||
| LZX.mgf | Mgf | |||
| LZX.raw | Raw | |||
| lzx_202109.fasta | Fasta |
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Publications
A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer.
Molecular cancer 20230422 1
<h4>Background</h4>Hypoxia is a hallmark of solid tumors and leads to the metabolic reprogramming of cancer cells. The role of epigenetic regulation between hypoxia and aberrant cholesterol metabolism in colorectal cancer (CRC) remains elusive.<h4>Methods</h4>Hypoxia-responsive circular RNAs (circRNAs) were identified by high throughput RNA sequencing between CRC cells cultured under normoxia or hypoxia. The protein-coding potential of circINSIG1 was identified by polysome profiling and LC-MS. T ...[more]
