Proteomics

Dataset Information

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Using BioID2 to map domain specific Ku70 protein interactors

ABSTRACT: To determine if the proximity-dependent biotin identification (BioID2) technique could identify and map domain and region specific protein interactors, we conducted BioID2 with various segments of the Ku70 protein in the HEK293 cell line and compared the different datasets. To our knowledge, this is the first study aimed at using BioID2 to directly identify domain and region specific protein interactors.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Sanna Abbasi  

LAB HEAD: Caroline Schild-Poulter

PROVIDER: PXD020165 | Pride | 2021-04-22

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
peptides_1_1_0_DVWA1.mzid.gz Mzid
peptides_1_1_0_DVWA_2.mzid.gz Mzid
peptides_1_1_0_DVWA_3.mzid.gz Mzid
peptides_1_1_0_HEK293_2.mzid.gz Mzid
peptides_1_1_0_HEK293_3.mzid.gz Mzid
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Publications

Identification of Ku70 Domain-Specific Interactors Using BioID2.

Abbasi Sanna S   Schild-Poulter Caroline C  

Cells 20210314 3

Since its inception, proximity-dependent biotin identification (BioID), an in vivo biochemical screening method to identify proximal protein interactors, has seen extensive developments. Improvements and variants of the original BioID technique are being reported regularly, each expanding upon the existing potential of the original technique. While this is advancing our capabilities to study protein interactions under different contexts, we have yet to explore the full potential of the existing  ...[more]

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