Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Homo Sapiens (human)
DISEASE(S): Cockayne Syndrome
SUBMITTER: Christina Ludwig
LAB HEAD: Christina Ludwig
PROVIDER: PXD024478 | Pride | 2021-11-16
REPOSITORIES: Pride
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BBM_321_P153_02_FRH_001.raw | Raw | |||
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Cells 20210628 7
Cockayne syndrome (CS) is a developmental disorder with symptoms that are typical for the aging body, including subcutaneous fat loss, alopecia, and cataracts. Here, we show that in the cells of CS patients, RNA polymerase I transcription and the processing of the pre-rRNA are disturbed, leading to an accumulation of the 18S-E intermediate. The mature 18S rRNA level is reduced, and isolated ribosomes lack specific ribosomal proteins of the small 40S subunit. Ribosomal proteins are susceptible to ...[more]