Dataset Information

The cleavage site identification of Gm11437 by LC-MSMS

ABSTRACT: This study first identified the gut-derived factor Famsin, which is the N-terminal cleavage product of the single-transmembrane protein Gm11437, revealed a new liver-gut signaling axes involved in the regulation of energy homeostasis

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture

SUBMITTER: Yiguo Wang

LAB HEAD: Yiguo Wang

PROVIDER: PXD024577 | Pride | 2023-03-21

REPOSITORIES: pride

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Publications

Famsin, a novel gut-secreted hormone, contributes to metabolic adaptations to fasting via binding to its receptor OLFR796.

Long Aijun A Liu Yang Y Fang Xinlei X Jia Liangjie L Li Zhiyuan Z Hu Jiang J Wu Shuang S Chen Chao C Huang Ping P Wang Yiguo Y

Cell research 20230217 4

The intestine is responsible for nutrient absorption and orchestrates metabolism in different organs during feeding, a process which is partly controlled by intestine-derived hormones. However, it is unclear whether the intestine plays an important role in metabolism during fasting. Here we have identified a novel hormone, famsin, which is secreted from the intestine and promotes metabolic adaptations to fasting. Mechanistically, famsin is shed from a single-pass transmembrane protein, Gm11437, ...[more]

PMID: 36806353

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