Dataset Information
PSCK9 knockdown in EndoC-bH1 cells at 72 h (DIA proteomics experiment)
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Type B Pancreatic Cell, Endocrine Pancreas, Cell Culture
SUBMITTER: 
Maria Ryaboshapkina
LAB HEAD: Raphael Scharfmann
PROVIDER: PXD027911 | Pride | 2022-04-07
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| PE273.log.txt | Txt | |||
| PE273.params | Other | |||
| PE273.setup.txt | Txt | |||
| PE273.sne | Other | |||
| PE273_PCSK9_72h_Global_1.raw | Raw |
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Publications
Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits.
The Journal of biological chemistry 20220602 7
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in the degradation of the low-density lipoprotein receptor. PCSK9 also targets proteins involved in lipid metabolism (very low-density lipoprotein receptor), immunity (major histocompatibility complex I), and viral infection (cluster of differentiation 81). Recent studies have also indicated that PCSK9 loss-of-function mutations are associated with an increased incidence of diabetes; however, the expression and function of PCSK9 i ...[more]
