Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Type B Pancreatic Cell, Endocrine Pancreas, Cell Culture
SUBMITTER: Maria Ryaboshapkina
LAB HEAD: Raphael Scharfmann
PROVIDER: PXD027913 | Pride | 2022-04-07
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
PCSK9_Secretome.sne | Other | |||
PE002.log.txt | Txt | |||
PE002.params | Other | |||
PE002.setup.txt | Txt | |||
PE002_2021_PCSK9_Secretome_Control1.raw | Raw |
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The Journal of biological chemistry 20220602 7
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in the degradation of the low-density lipoprotein receptor. PCSK9 also targets proteins involved in lipid metabolism (very low-density lipoprotein receptor), immunity (major histocompatibility complex I), and viral infection (cluster of differentiation 81). Recent studies have also indicated that PCSK9 loss-of-function mutations are associated with an increased incidence of diabetes; however, the expression and function of PCSK9 i ...[more]