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Proteomics results of mouse testis after NHWD870 treatment

ABSTRACT: NHWD870 is a small molecule compound targeting Brdt. Testicular proteomics data obtained after intragastric administration of NHWD870 to six-week-old mice.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Testis, Testicular Artery

SUBMITTER: Sixian Wu

LAB HEAD: Wenming Xu

PROVIDER: PXD028773 | Pride | 2023-05-10

REPOSITORIES: Pride

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The novel BRDT inhibitor NHWD870 shows potential as a male contraceptive in mice.

Wu Sixian S Li Xiaoliang X Shang Lijun L Wu Lvying L Li Tongtong T Li Peiyv P Ji Zhiliang Z Hou Jianwen J Yin Mingzhu M Xu Wenming W

Acta biochimica et biophysica Sinica 20220901 12

Small molecule inhibitors of the bromodomain and extraterminal domain (BET) family proteins have emerged as promising options not only for the treatment of multiple cancers but also for disturbing the process of sperm maturation with potential for use as viable contraceptive targets. In this study, we find that the BET family inhibitor NHWD870 and BRDT can bind well <i>in vitro</i> through bioinformatics software prediction and protein binding inhibition experiments. NHWD870 can produce a good c ...[more]

PMID: 36239350

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	Oxidation__M_Sites.txt	Txt
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