Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Suspension Culture
SUBMITTER: Simone Pellegrino
LAB HEAD: Alan John Warren
PROVIDER: PXD031525 | Pride | 2023-07-20
REPOSITORIES: Pride
Action | DRS | |||
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P784_201020.sf3 | Other | |||
P784_Human_40S.raw | Raw |
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Pellegrino Simone S Dent Kyle C KC Spikes Tobias T Warren Alan J AJ
Nucleic acids research 20230501 8
The chemical modification of ribosomal RNA and proteins is critical for ribosome assembly, for protein synthesis and may drive ribosome specialisation in development and disease. However, the inability to accurately visualise these modifications has limited mechanistic understanding of the role of these modifications in ribosome function. Here we report the 2.15 Å resolution cryo-EM reconstruction of the human 40S ribosomal subunit. We directly visualise post-transcriptional modifications within ...[more]