Dataset Information

An integrative transcriptomic and proteomic analysis of an industrial clavulanic acid-overproducing Streptomyces clavuligerus

ABSTRACT: Clavulanic acid is a clinically-important secondary metabolite used in treatment of infectious diseases. We aimed to decipher complex regulatory mechanisms acting in clavulanic acid biosynthesis through the analysis of transcriptome- and proteome-wide alterations in an industrial clavulanic acid overproducer Streptomyces clavuligerus, namely DEPA and its wild-type counterpart NRRL3585.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Streptomyces Clavuligerus

SUBMITTER: Servet ÖZCAN

LAB HEAD: Servet Ozcan

PROVIDER: PXD032272 | Pride | 2022-11-02

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	160308_W1SA_FASP_Eser_METU_SOZSET11.wiff	Wiff
	160308_W1SA_FASP_Eser_METU_SOZSET11.wiff.scan	Wiff
	160308_W1SA_FASP_Eser_METU_SOZSET11_MGFPeaklist.mgf	Mgf
	160308_W1SA_FASP_Eser_METU_SOZSET11_PeptideSummary.txt	Txt
	160308_W1SA_FASP_Eser_METU_SOZSET11_ProteinSummary.txt	Txt

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Publications

An integrative-omics analysis of an industrial clavulanic acid-overproducing Streptomyces clavuligerus.

Kurt-Kızıldoğan Aslıhan A Çelik Gözde G Ünsaldı Eser E Özcan Servet S Ayaz-Güner Şerife Ş Özcengiz Gülay G

Applied microbiology and biotechnology 20220810 18

Clavulanic acid (CA) is a clinically important secondary metabolite used to treat infectious diseases. We aimed to decipher complex regulatory mechanisms acting in CA biosynthesis by analyzing transcriptome- and proteome-wide alterations in an industrial CA overproducer Streptomyces clavuligerus strain, namely DEPA and its wild-type counterpart NRRL3585. A total of 924 differentially expressed genes (DEGs) and 271 differentially produced proteins (DPPs) were obtained by RNA-seq and nanoLC-MS/MS ...[more]

PMID: 35945361

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