Dataset Information
Whole proteome analysis of leukocytes isolated from peripheral blood of patients with sex determination defects and germ cell tumors, occurred in Swyer and CAIS.
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Leukocyte
SUBMITTER: 
Marcin Luzarowski
LAB HEAD: Maria Krivega
PROVIDER: PXD033635 | Pride | 2023-07-20
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Q25070-22-2-01.raw | Raw | |||
| Q25070-22-2-02.raw | Raw | |||
| Q25070-22-2-03.raw | Raw | |||
| Q25070-22-2-04.raw | Raw | |||
| Q25070-22-2-05.raw | Raw |
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Publications
Genomic instability in individuals with sex determination defects and germ cell cancer.
Cell death discovery 20230523 1
The ability to transmit genetic information through generations depends on the preservation of genome integrity. Genetic abnormalities affect cell differentiation, causing tissue specification defects and cancer. We addressed genomic instability in individuals with Differences of Sex Development (DSD), characterized by gonadal dysgenesis, infertility, high susceptibility for different types of cancer, especially Germ Cell Tumors (GCT), and in men with testicular GCTs. Whole proteome analysis of ...[more]
