Dataset Information

Serum differential proteomic profiling of patients with isolated methylmalonic acidemia by iTRAQ

ABSTRACT: The serum for 3 MMA patients and 3 healthy subjects were used for LC-MS/MS.Quantitative proteomic profiling of serum of patients with isolated MMA by iTRAQ labeling.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

SUBMITTER: Hu Hao

LAB HEAD: Hu Hao

PROVIDER: PXD034075 | Pride | 2022-10-13

REPOSITORIES: pride

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			Action	DRS
	20201004.sld	Other
	20201004_20201007125444.sld	Other
	20201004_20201010182614.sld	Other
	20201004_20201012090529.sld	Other
	20201004_20201012152641.sld	Other

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Serum differential proteomic profiling of patients with isolated methylmalonic acidemia by iTRAQ.

Li Sitao S Shi Congcong C Cai Yao Y Gu Xia X Xiong Hui H Liu Xiaoyu X Zhang Yinchun Y Xiao Xin X Ma Fei F Hao Hu H

Frontiers in genetics 20220829

Isolated methylmalonic acidemia (MMA) is an inherited organic acid metabolic disorder in an autosomal recessive manner, caused by mutations in the methylmalonyl coenzyme A mutase gene, and the isolated MMA patients often suffer from multi-organ damage. The present study aimed to profile the differential proteome of serum between isolated MAA patients and healthy control. The <i>in vivo</i> proteome of isolated MAA patients and healthy subjects was detected by an isobaric tag for relative and abs ...[more]

PMID: 36105101

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